Doxorubicin thioesters

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...

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536 4, 536 17, 536121, A61K 3165, C07H 1524

Patent

active

040988848

ABSTRACT:
Doxorubicin thioesters of the formula ##STR1## wherein R is acyl and which are useful in treating animal tumors, are prepared by reacting 14-bromo-daunomycin with a salt of a thioacid of the formula RSM wherein R is as defined above and M is an alkali metal atom or a quaternary ammonium salt in an inert polar solvent. The invention described herein was made in the course of work under a grant from the Department of Health, Education, and Welfare.

REFERENCES:
patent: 4024224 (1977-05-01), Arcamone et al.
patent: 4031211 (1977-06-01), Patelli et al.
patent: 4035566 (1977-07-01), Israel et al.
Pigman, "The Carbohydrates", 1957, Academic Press Inc., New York, N. Y. p. 160.

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