Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1977-03-10
1978-07-04
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
536 4, 536 17, 536121, A61K 3165, C07H 1524
Patent
active
040988848
ABSTRACT:
Doxorubicin thioesters of the formula ##STR1## wherein R is acyl and which are useful in treating animal tumors, are prepared by reacting 14-bromo-daunomycin with a salt of a thioacid of the formula RSM wherein R is as defined above and M is an alkali metal atom or a quaternary ammonium salt in an inert polar solvent. The invention described herein was made in the course of work under a grant from the Department of Health, Education, and Welfare.
REFERENCES:
patent: 4024224 (1977-05-01), Arcamone et al.
patent: 4031211 (1977-06-01), Patelli et al.
patent: 4035566 (1977-07-01), Israel et al.
Pigman, "The Carbohydrates", 1957, Academic Press Inc., New York, N. Y. p. 160.
Arcamone Federico
Bernardi Luigi
Patelli Bianca
Brown Johnnie R.
Societa Farmaceutici Italia S.p.A.
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