Double transgenic mice overexressing human beta secretase...

Details Double transgenic mice overexressing human beta secretase... Double transgenic mice overexressing human beta secretase...

2007-07-24

2007-07-24

Sullivan, Daniel M. (Department: 1636)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S003000, C800S012000, C800S022000, C800S025000, C435S354000

Reexamination Certificate

active

10372730

ABSTRACT:
The present invention relates to a novel animal model for amyloidopathies, especially Alzheimer' disease overexpressing human BACE and human APP London. This novel animal model exhibits several aspects of amyloidopathy. The present invention also relates to a method for producing the double transgenic animals, to cells and cell lines derived from these animals and to a kit comprising these cells. Moreover, a method for the evaluation of the in vivo effects of beta-secretase activity on A-beta peptide generation, amyloidosis, neurodegeneration and AD pathology in these animals is provided.

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