Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2007-06-12
2007-06-12
Priebe, Scott D. (Department: 1633)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S363000, C435S455000
Reexamination Certificate
active
10729861
ABSTRACT:
Described is a double-transfected cell line containing (a) a DNA sequence encoding an uptake transporter for organic anions, preferably OATP8, operatively linked with a promoter and (b) a DNA sequence encoding an export pump for organic anions or anionic conjugates, preferably the multidrug resistance protein 2 (MRP2), operatively linked with a promoter. Moreover, various uses of said cell line are described, preferably its use for the identification of transport inhibitors, e.g. drug candidates.
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Cui Yunhai
Keppler Dietrich
Koenig Joerg
Burkhart Michael
Deutches Krebsforschungszentrum Stiftung des Offentlichen Rechts
Priebe Scott D.
Schwegman, Lundberg, Woessner and Kluth P.A.
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