Double transfectants of the MHC genes as cellular vaccines for i

Details Double transfectants of the MHC genes as cellular vaccines for i Double transfectants of the MHC genes as cellular vaccines for i

1995-03-29

1998-05-12

Stanton, Brian R.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 937, 435 696, 435325, 435347, 435366, 935 71, A61K 3512, C12N 508, C12N 1506, C12N 1509

Patent

active

057501025

ABSTRACT:
The present invention relates to anti-tumor vaccines comprising at least one type of tumor cell into each of which at least two genes encoding MHC proteins of different haplotypes have been inserted, or naturally expressed, said genes being expressed in said tumor cells and wherein at least one of said MHC proteins has the same haplotype as a haplotype of the individual to be vaccinated. The invention furthermore relates to a method of treating a patient suffering from a tumorous disease comprising administering a vaccine of the invention and to the use of a vaccine of the invention for the preparation of an anti-tumor vaccine.

REFERENCES:
Freshney, in "Culture of Animal Cells: A Manual of Basic Technique," Alan R. Liss, Inc., N.Y. 1987 pp. 9 and 10.
Roemer et al. 1992 Eur J. Biochem 208:211-225.
Ledley 1991 Human Gene Therapy 2:77-83.
Ostrand-Rosenberg et al. 1991 Int J Cancer Supplement 6:61-68.
Cordon-Cardo et al. 1991 Cancer Research 51:6372-6380.
Anderson, 1984 Science 226:401-409.
Rodriguez et al. (ed) 1988 in "Vectors: A Survey of Molecular Cloning Vectors and Their Uses", Butterworths, Boston pp. 467-513.
F. Brodsky et al., Annu. Rev. Immunol. 9:707-744 (1991).
L. Eisenbach et al., Haematology & Blood Tran. 29:499-507, Modern Trends in Human Leukemia VI (1985).
L. Eisenbach et al., Int. J. Cancer 32:113-120 (1983).
L. Eisenbach et al., Immunomodulation of Tumor Metastases (in New Exp. Modalities in the Cont. of Neoplasia) pp. 81-90 (1986).
L. Eisenbach et al., Seminars in Cancer Biology 2:179-188 (1991).
I. Fidler et al., Science 197:893-895 (1977).
C. Gelber et al., Cancer Research 49:2366-2373 (1989).
L. Hood et al., Ann. Rev. Immunol. 1:529-568 (1983).
D. Perkins et al., J. Exp. Med., 170:279-289 (1989).
D. Plaskin et al., Proc. Natl. Acad. Sci. USA 85:4463-4467 (1988).

Affiliated with

Also associated with

Rating

Double transfectants of the MHC genes as cellular vaccines for i does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Double transfectants of the MHC genes as cellular vaccines for i, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Double transfectants of the MHC genes as cellular vaccines for i will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-976798