Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-05-13
1999-01-12
Fredman, Jeffrey
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 4353201, 4352402, 4352523, 536 231, 536 243, 536 2431, 536 2433, C12Q 168, C12P 1934, C07H 2102, C07H 2104
Patent
active
058586750
ABSTRACT:
The present invention provides a double-stranded RNA-binding protein (BINDR) and polynucleotides which identify and encode BINDR. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of BINDR.
REFERENCES:
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Hillier et al genbank record (publicly available Apr. 02, 1996) Genbank Accession record N76259, (submitted 1995), Apr. 1996.
Sambrook et al (Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York) page 17.2, 1989.
Burd, C.G. et al., "Conserved Structures and Diversity of Functions of RNA-Binding Proteins", Science, 265: 615-621 (1994).
St. Johnston, D. et al., "A conserved double-stranded RNA-binding domain", Proc. Natl. Acad. Sci., 89: 10979-10983 (1992).
Gatignol, A. et al., "Sequential Steps in Tat Trans-Activation of HIV-1 Mediated Through Cellular DNA, RNA, and Protein Binding Factors", Gene Expression, 5: 217-228 (1996).
Benkirane, M. et al., "Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR", EMBO J. , 16: 611-624 (1997).
Lee, K. et al., "A Testis Cytoplasmic RNA-Binding Protein That Has the Properties of a Translational Repressor", Mol. Cell. Biol., 16: 3023-3034 (1996) (GI 1737216).
Jantsch, M.F. et al., (Direct Submission), GenBank Sequence Database (Accession M96370), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 214738) (GI 214739) (1992).
Gatignol, A. et al., (Direct Submission), GenBank Sequence Database (Accession U08998), National Center for Biotechnology Information , National Library of Medicine, Bethesda, Maryland, 20894 (GI 478989) (GI 478990) (1997).
Corley Neil C.
Hillman Jennifer L.
Lal Preeti
Billings Lucy J.
Fredman Jeffrey
Incyte Pharmaceuticals Inc.
Mohan-Peterson Sheela
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