Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-05-23
2006-05-23
Ponnaluri, Padmashri (Department: 1639)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091500, C435S091500, C435S091500, C435S091500, C435S091500, C435S091500, C435S091500, C435S174000, C435S180000, C436S518000, C436S528000, C436S529000, C536S023100, C536S025300, C549S223000, C549S227000
Reexamination Certificate
active
07049073
ABSTRACT:
This invention describes a new method of constructing double-stranded DNA (dsDNA) microarrays based on the use of pre-synthesized or natural DNA duplexes without a stem-loop structure. The complementary oligonucleotide chains are bonded together by a novel connector that includes a linker for immobilization on a matrix. A non-enzymatic method for synthesizing double-stranded nucleic acids with this novel connector enables the construction of inexpensive and robust dsDNA/dsRNA microarrays. DNA-DNA and DNA-protein interactions are investigated using the microarrays.
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Chernov Boris
Golova Julia
Barnes & Thornburg LLP
Martin Alice O.
Ponnaluri Padmashri
The University of Chicago
Tran My-Chau T.
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