Double recombinant vaccinia virus vaccines

Details Double recombinant vaccinia virus vaccines Double recombinant vaccinia virus vaccines

1991-06-17

1998-02-17

Smith, Lynette F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4241841, 4241921, 4351721, 435948, 536 231, A61K 39155, A61K 3900, C12N 1500, C07H 2102

Patent

active

057189021

ABSTRACT:
Vaccines comprising a recombinant vaccinia virus expressing at least two heterologous genes encoding pathogen antigens are described. A first antigen gene is inserted into the thymidine kinase gene of the vaccinia virus and a second antigen gene is inserted into the hemagglutinin gene of the vaccinia virus. In particular, the hemagglutinin and fusion genes of the rinderpest virus have been inserted into the thymidine kinase and hemagglutinin genes of the vaccinia virus, respectively. Such double recombinant viruses have been found to be highly attenuated while remaining effective in protecting an inoculated host.

REFERENCES:
patent: 4722848 (1988-02-01), Paoletti et al.
Yilma et al. (1988) Science 242:1058-1061.
Yilma (1990) Biotechnology 8:1007-1009.
Perkus et al. (1985) Science 229:981.
Buller et al. (1985) Nature 317:813.

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