Double prodrugs of potent GP IIb/IIIa antagonists

Details Double prodrugs of potent GP IIb/IIIa antagonists Double prodrugs of potent GP IIb/IIIa antagonists

1999-05-19

2000-02-15

McKane, Joseph K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514424, 544372, 548550, A61K 3140, A61K 31495, C07D40312, C07D20724

Patent

active

060253584

ABSTRACT:
The present invention relates to double prodrugs of pharmacologically active glycoprotein IIb/IIIa antagonists of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of lower alkyl of about 2 to about 8 carbon atoms, cycloalkyl, and aralkyl; R is selected from the group consisting of alkoxy, ##STR2## wherein R.sup.50 is H or alkyl; and ##STR3## wherein R.sup.50 is H or alkyl; and pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 5344957 (1994-09-01), Bovy et al.
patent: 5484946 (1996-01-01), Abood et al.
patent: 5576447 (1996-11-01), Abood et al.
patent: 5610296 (1997-03-01), Abood et al.
patent: 5721366 (1998-02-01), Abood et al.
J. Med. Chem., vol. 39, Weller et al., pp. 3139-3147, 1996.
Pharmazie, vol. 43, Hauptmann et al., pp. 559-560, 1988.

Affiliated with

Also associated with

Rating

Double prodrugs of potent GP IIb/IIIa antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Double prodrugs of potent GP IIb/IIIa antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Double prodrugs of potent GP IIb/IIIa antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1906128