Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Oxidoreductases
Reexamination Certificate
2005-05-03
2005-05-03
Saidha, Tekchand (Department: 1652)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Oxidoreductases
C435S193000, C435S252300, C435S320100, C536S023200, C530S350000
Reexamination Certificate
active
06887467
ABSTRACT:
New mutant forms of human dihydrofolate reductase (DHFR) which have properties superior to the previously disclosed mutants have mutations at both amino acid22and amino acid31. Specific mutant forms are Ser31Tyr22, Ser31Phe22, Gly31Tyr22, Gly31Phe22, Ala31Tyr22 and Ala31Phe22. The mutant DHFR of the invention may be used as a selectable marker, and to modify the genome of human cells, particularly bone marrow cells or peripheral blood stem cells, to render them resistant to chemotherapy using antifolate agents.
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patent: WO 9733988 (1997-09-01), None
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Banerjee Debabrata
Bertino Joseph R.
Ercikan-Abali Emine A.
Mineishi Shin
Sadelain Michel
Oppedahl & Larson LLP
Saidha Tekchand
Sloan-Kettering Institute for Cancer Research
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