Double mutant enterotoxin for use as an adjuvant

Details Double mutant enterotoxin for use as an adjuvant Double mutant enterotoxin for use as an adjuvant

1998-03-18

2000-03-07

Housel, James C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4242411, 4242821, 4242781, 4241841, 424832, 424 92, 514885, A61K 3902, A61K 39108, A61K 4500, X61K 3900

Patent

active

060336730

ABSTRACT:
The present invention is directed towards a novel composition which is a genetically distinct mutant of E. coli heat-labile enterotoxin (LT). Specifically, the mutant LT designated LT(R192G/L211A) is modified by two amino acid substitutions, i.e., the arginine at amino acid position 192 is replaced by glycine and the leucine at amino acid position 211 is replaced by alanine. The invention relates to compositions and methods for use of the novel double mutant of LT as an adjuvant.

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