Double motor mutant assay for antifungal agents

Details Double motor mutant assay for antifungal agents Double motor mutant assay for antifungal agents

2005-06-14

2005-06-14

Bell, Kent (Department: 1661)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

C435S006120, C435S015000, C435S029000

Reexamination Certificate

active

06905840

ABSTRACT:
Provided are methods of identifying potential antifungal agents, and particularly those having antimitotic activity. Fungal cells having double mutations which alter microtubule stability and inhibit cell proliferation are used in the methods. Test compounds are screened to identify those which are able to promote cell proliferation o the mutant fungal cells and counteract the stabilizing effect of the double mutations on the microtubules. High-throughput methods of selecting for the novel antifungal agents are also provided.

REFERENCES:
patent: 5418144 (1995-05-01), Kirsch et al.
DeZwann, et al., “Kinesin-related KIP3 ofSaccharomyces cerevisiaeIs Required for a Distinct Step in Nuclear Migration”, The Journal of Cell Biology, vol. 138, 1997, pp. 1023-1040.

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