Double copy retroviral vector

Details Double copy retroviral vector Double copy retroviral vector

1995-01-31

1997-08-19

Fleisher, Mindy

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 691, 4353201, C12N 1586, C12N 510

Patent

active

056587759

ABSTRACT:
The present invention concerns a retroviral vector for introducing into a eucaryotic cell DNA encoding a transcription unit which comprises a first DNA sequence which is the reverse transcript of at least a portion of a retrovirus, said portion including both the 5' LTR sequence and the 3' LTR sequence of the retrovirus, and a second DNA sequence encoding the transcription unit which is inserted into the U3 region of the 3' LTR sequence. A method of producing a virion useful for introducing into a eucaryotic cell DNA encoding a transcription unit is provided as well as a method of introducing into a eucaryotic cell DNA encoding a transcription unit which comprises infecting the cell with such a virion.

REFERENCES:
patent: 5324643 (1994-06-01), Greatbatch et al.
M.A. Lopata et al (1986) Proc Nat. Acad. Sci USA 83:6677-6681.
L.I. Lobel et al (1985) Science 228:329-332.
W. Reik et al (1985) Proc. Natl. Acad. Sci. USA 82: 1141-1145.
L.I. Lobel et al (1984) Proc. Natl. Acad. Sci. USA 81: 4149-4153.
H. Temin (1986) In: Gene Transfer, (Ed: R. Kucherlapati) Plenum Press, NY, 149-187.
J. P. Dougherty et al (1987) Proc. Natl. Acad. Sci. USA 84: 1197-1201.

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