Double antibody conjugate

Details Double antibody conjugate Double antibody conjugate

1981-09-08

1984-02-21

Nucker, Christine M.

Chemistry: analytical and immunological testing

Involving antibody fragments

436528, 436540, 436814, 436820, 436823, 436824, 436520, G01N 3354, G01N 3358, G01N 3360

Patent

active

044330596

ABSTRACT:
Reagents and methods are described for an immunoassay test of increased sensitivity and decreased complexity employing an immunoglobulin specific for an antigen naturally or artificially placed upon the surface of an indicator particle coupled through the use of a hetero-bifunctional coupling reagent to a second antibody of differing specificity and specific for the antigen to be detected. In a preferred embodiment, a hetero-bifunctional coupling agent couples via a sulfhydryl group, a univalent immunoglobulin specific for the surface antigens on erythrocytes to a second multivalent immunoglobulin through an amide linkage with the latter immunoglobulin wherein said second immunoglobulin is specific for hepatitis-B surface antigen.

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patent: 4342566 (1982-08-01), Theofilopoulos et al.
Pain et al., J. Immunological Methods 40(1981), 219-230.
Kitagawa et al., Chem. Abstracts, 91(1979) #204049m.

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