Dota-biotin derivatives

Details Dota-biotin derivatives Dota-biotin derivatives

1997-12-15

2000-09-19

Huff, Sheela

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

4241831, 424 153, 4241811, 424 91, 424 93, 424 149, 424 141, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 530331, A61K 39395

Patent

active

061207683

ABSTRACT:
A radionuclide-chelator conjugate composition for detecting and/or treating lesions in a patient in a pre-targeting protocol which comprises pre-targeting the target cell, tissue, or pathogen with a substrate, using a targeting protein that specifically binds a marker substance on the target cell, tissue, or pathogen and to which the substrate is directly or indirectly bound; parenterally injecting the detection or therapeutic composition of the invention which comprises a chelate conjugate of biotin, a chelator, and a chelatable detection or therapeutic agent, and allowing the composition to accrete at the targeted cell, tissue, or pathogen; wherein the chelate conjugate is purified by chromatography after chelate formation, or further comprises a blood transit-modifying linker or addend that is covalently bound within the chelate conjugate, or both; and using the detection or therapeutic agent to detect or treat the targeted cell, tissue, or pathogen.

REFERENCES:
patent: 4624846 (1986-11-01), Goldenbeg et al.
patent: 4732864 (1988-03-01), Tolman
patent: 4782840 (1988-11-01), Martin, Jr. et al.
patent: 4863713 (1989-09-01), Goodwin et al.
patent: 4932412 (1990-06-01), Goldenberg
patent: 5202451 (1993-04-01), Fritzberg et al.
patent: 5283342 (1994-02-01), Gustaavson et al.
patent: 5326778 (1994-07-01), Rosebrough
patent: 5428156 (1995-06-01), Mease et al.
patent: 5443813 (1995-08-01), Hainfield
patent: 5525338 (1996-06-01), Goldenberg et al.
patent: 5556982 (1996-09-01), Fritzberg et al.
Kalofonos, H. P. et al., "Imaging of Tumor in Patients with Indium-111-Labeled Biotin and Streptavidin-Conjugated Antibodies: Preliminary Communication", Journal of Nuclear Medicine, 31:1791-1796 (1990).
Paganelli, P. et al., "Tumor Targeting in Patients with Ovarian Cancer Using Biotinylated Monoclonal Antibodies and Radioactive Streptavidin", Scientific Papers, Proceedings of the 37th Annual Meeting, vol. 31, No. 5 (May 1990).
Hainfeld, J. F., "Uranium-loaded Apoferritin with Antibodies Attached: Molecular Design for Uranium Neutron-capture Therapy", Proc. Natl. Acad. Sci. USA, vol. 89, 11064-11068 (Nov. 1992).
Osband, et al, Immuunol. Today, 11:193, 1990, Problems . . . immunotherapy.
Harris, et al. Tibtech, 11:42, 1993, Therapeutic . . . Age.
Goodwin "Tumor Pretargeting: Almost the Bottom Line," J. Nucl. Med. 36(5): 876-879 (May, 1995).
Hawkins et al. "Delivery of Radionuclides to Pretargeted Monoclonal Antibodies Using Dihydrofolate Reductase and Methotrexate in an Affinity System, " Cancer Research 53: 2368-2373 (1993).
Bos et al. "In Vitro Evaluation of DNA-DNA Hybridization as a Two-Step Approach in Radioimmunotherapy of Cancer," Cancer Research 54: 3479-3486 (1994).
Losman et al. "Mimicry of a Carcinoembryonic Antigen Epitope by a Rat Monoclonal Anti-idiotype Antibody," Int. J. Cancer 56: 580-584 (1994).
Sharkey, et al. "Enhanced Clearance of Radiolabeled Murine Monoclonal Antibody by a Syngeneic Anti-Idiotype Antibody in Tumor-Bearing Nude Mice," Int. J. Cancer 51: 266-273 (1992).
Goodwin, D. A. et al., "Pre-Targeted Immunoscintigraphy of Murine Tumors with Indium-111-Labeled Bifunctional Haptens", The Journal of Nuclear Medicine, 29:226-234 (1988).
Hnatowich, D. J. et al., "Investigations of Avidin and Biotin for Imaging Applications", The Journal of Nuclear Medicine, 28:1294-1302 (1987).
Oehr, P. et al., "Streptavidin and Biotin as Potential Tumor Imaging Agents", The Journal of Nuclear Medicine, 29:728-729 (May 1988).
Yuan, Fan, "Pharmacokinetic Analysis of Two-Step Approaches Using Bifunctional and Enzyme-conjugated Antibodies", Cancer Research 51, 3119-3130 (Jun. 15, 1991).
Paganelli, G., "In Vivo Labelling of Biotinylated Monoclonal Antibodies by Radioactive Avidin: A Strategy to Increase Tumor Radiolocalization", Int. J. Cancer: Supplement 2, 121-125 (1988).

Affiliated with

Also associated with

Rating

Dota-biotin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dota-biotin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dota-biotin derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1069419