DOT1 histone methyltransferases as a target for identifying...

Details DOT1 histone methyltransferases as a target for identifying... DOT1 histone methyltransferases as a target for identifying...

2004-06-14

2008-10-28

Fetterolf, Brandon J (Department: 1642)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000

Reexamination Certificate

active

07442685

ABSTRACT:
The present invention provides polypeptides with histone H3 lysine 79 methyltransferase activity as well as nucleic acids encoding the same. Also provided are methods of using the polypeptides and nucleic acids of the invention in screening assays to identify compounds of interest. Further provided are diagnostic methods for leukemia and prognostic methods to predict the course of the disease in a subject.

REFERENCES:
patent: 6251594 (2001-06-01), Gonzalgo et al.
patent: 6555329 (2003-04-01), Jenuwein et al.
patent: 2003/0157532 (2003-08-01), Jenuwein et al.
patent: 2004/0053233 (2004-03-01), Lorens et al.
patent: WO 03/016497 (2003-02-01), None
patent: WO03/016497 (2003-02-01), None
patent: WO 03016497 (2003-02-01), None
Feng et al. (Current Biology 2002; 12: 1052-1058).
Accession No. AAC08316, NCBI Database.
Accession No. AF509504, NCBI Database.
Accession No. AAF54122, NCBI Database.
Accession No. AAN13378, NCBI Database.
Accession No. AAN13379, NCBI Database.
Accession No. AAN13380, NCBI Database.
Accession No. BAB84946, NCBI Database.
Accession No. CAA90610, NCBI Database.
Accession No. EAA03558, NCBI Database.
Accession No. EAA33634, NCBI Database.
Accession No. NP—010728, NCBI Database.
Accession No. NP—115871, NCBI Database.
Accession No. NP—510056, NCBI Database.
Accession No. NP—649655, NCBI Database.
Accession No. NP—731084, NCBI Database.
Accession No. NP—731085, NCBI Database.
Accession No. NP—731083, NCBI Database.
Accession No. Q8TEK3, NCBI Database.
Accession No. Q04089, NCBI Database.
Accession No. XP—125730, NCBI Database.
GenBank Accession No. BF982417 (Jan. 22, 2001).
GenBank Accession No. BF507396 (Dec. 6, 2000).
Dlakiċ, M.; “Chromatin silencing protein and pachytene checkpoint regulator Dot1p has a methyltransferase fold,”Trends in Biochemical Sciences26:7 405-407 (Jul. 2001).
Feng et al.; “Methylation of H3-Lysine 79 is mediated by a new family of HMTases without a SET domain,”Current Biology12: 1052-1058 (Jun. 2002).
Lacoste et al., “Disruptor of Telomeric Silencing-1 is a chromosome-specific histone H3 methyltransferase,”Journal of Biological Chemistry277:34 30421-30424 (2002).
Min et al., “Structure of the catalytic domain of human DOT1L, a non-set domain nucleosomal histone methyltransferase,”Cell112: 711-723 (Mar. 2003).
Ng et al., “Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association,”Genes&Development16: 1518-1527 (2002).
San-Segundo et al., “Role for the silencing protein Dot1 in Meiotic checkpoint control,”Molecular Biology of the Cell11 3601-3615 (Oct. 2000).
Singer et al., “Identification of high-copy disruptors of telomeric silencing inSaccharomyces cerevisiae,” Genetics150 613-632 (Oct. 1998).
Van Leeuwen, et al., “Dot1p modulates silencing in yeast by methylation of the nucleosome core,”Cell109 745-756 (Jun. 2002).
Zhang, Yi, (Oral Presentation) “hDOT1L, a histone methyltransferase without a SET domain is involved in leukemogenesis,” 28thLineberger Cancer Symposium, “Epigenetics, Chromatin and Cancer,” UNC-CH, Chapel Hill, NC, USA (Apr. 20, 2004).

Affiliated with

Also associated with

Rating

DOT1 histone methyltransferases as a target for identifying... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DOT1 histone methyltransferases as a target for identifying..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DOT1 histone methyltransferases as a target for identifying... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4018909