Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1991-07-09
1992-08-18
Warden, Robert J.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
43524023, 435240241, 4352404, 435243, 435818, C12N 506, C12N 508, C12N 504, C12N 100
Patent
active
051399466
ABSTRACT:
There is disclosed a perfusable cell culture device capable of expansion and maintenance of biological cells, including mammalian, microbial, plant and insect cells in culture. The device comprises an upper and lower polymeric film layer and a gas and liquid permeable flow divider membrane. The flow divider membrane is affixed between the upper and lower polymeric layers and to the lower polymeric layer in a manner providing channels for fluid distribution of culture medium which is perfused at a controlled rate, uniformly across the flow divider membrane and to a bed of cells dispersed on the flow divider membrane.
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Howell Gary W.
Irr Joseph D.
Nahapetian Ara T.
Beisner William H.
Du Pont Merck Pharmaceutical Company
Ferguson Blair Q.
Horn Margaret
Warden Robert J.
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