Dosing regimen

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

active

06838467

ABSTRACT:
This invention relates to a method of treatment and dosing regimen for treating mammalian tumors by the discontinuous administration of a farnesyl transferase inhibitor over an abbreviated one to five day dosing schedule.

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Parada L. F. et al. “Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene,”Nature, 1982, pp. 474-478, vol. 297, No. 5866.
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Kohl et al., “Selective Inhibition of ras-Dependent Transformation by a Farnesyltransferase Inhibitor,”Science, 1993, pp. 1934-1937, vol. 260, No. 5116.

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