Dispensing – Inspection devices – Graduated transparent container or trap
Patent
1999-01-29
2000-12-19
Shaver, Kevin
Dispensing
Inspection devices
Graduated transparent container or trap
222257, 222260, 2223211, 2223213, B67D 538
Patent
active
061617318
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
This invention relates to a dosing device for flowable substances, in particular liquids to be sprayed, having a storage vessel for the substance to be dosed and feed means which transports the substance to the discharge opening of the dosing device.
Such dosing devices are known in the form of pump-spray systems which allow liquids, pharmaceutical solutions for example, to be sprayed The known systems first have to be primed by filling the dosing pump, the user being unable to check from which point in time the dosing pump is completely filled and therefore from which point in time the full amount of solution assigned to a pumping movement is sprayed. Therefore, with known pump-spray systems it is not possible to achieve the dosing accuracy of five per cent typically required by registration authorities for medicaments with the dosing pumps available on the market.
Furthermore, the previously known pump-spray systems do not allow a dry substance to be dissolved or suspended in a suitable solvent just before application to the patient and, after the substance has been dissolved or suspended, to be applied precisely and under sterile conditions from a gas-free, e.g. airless, reservoir.
SUMMARY OF THE INVENTION
The present Applicants have sought to overcome shortcomings of known devices for administration to, e.g. wounds.
The present invention is based on the object of providing a dosing device which can be easily used in a straightforward manner and allows a quantitatively exact and aseptic application of an active agent in solution or suspension, i.e. which contains drug product, even at body surfaces where access is difficult.
This object is achieved according to this invention by connecting a storage vessel to feed means in such a way that the vessel is sealed off from the outside on all sides and there being provided in the wall of the storage vessel a closure element which, when the storage vessel is emptied, is subjected to a force caused by the external air pressure and has the effect that the shape of the storage vessel can be changed in the region of the closure element, and by there being provided indicating means which is assigned to the movement of the closure element and has the effect that the extent of the movement of the closure element, and consequently the amount of substance discharged, can be indicated.
It is particularly advantageous to use as the feed means a dosing pump for a gas-free sealed system which can be actuated by an abrupt pushing movement of a chosen spray head. In one embodiment of this invention, the storage vessel is formed by the syringe body of a plunger syringe and the closure element is formed by the syringe plunger of the plunger syringe.
The indicating device assigned to the syringe plunger serving as the closure element makes it possible to achieve dosing accuracy of five per cent required by registration authorities for medicaments irrespective of the dosing accuracy of the dosing pump, since the dosage is no longer measured by counting the thrusts of the dosing pump but by reading off from the scale assigned to the closure element, in particular the syringe plunger.
In another embodiment of the invention, the plunger rod of the plunger syringe is detachably connected to the syringe plunger in order to prevent the plunger rod from causing any hindrance.
If the storage vessel is not manufactured all in one from a transparent material, it is advantageous if the respective position of the plunger can be seen from outside through a transparent region in the cylindrical portion of the storage vessel and the transparent region is provided with the scale. In the simplest case, the storage vessel comprises a transparent ready-to-use syringe provided with a printed-on scale.
The active agent may be in the form of a lyophilisate which may have to be reconstituted prior to administration e.g. to a wound.
It is also possible, however, to design the storage vessel as the first chamber of a double-chamber syringe which contains active agent to b
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Deal David
Lee Michael U.
Novartis AG
Shaver Kevin
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