Surgery – Radioactive substance applied to body for therapy – Radioactive substance placed within body
Reexamination Certificate
2006-10-10
2006-10-10
Gilbert, Samuel G. (Department: 3735)
Surgery
Radioactive substance applied to body for therapy
Radioactive substance placed within body
C600S008000
Reexamination Certificate
active
07118524
ABSTRACT:
The present invention discloses a methodology for the characterization and determination of mixed-field dosimetry for252Cf Applicator Tube (AT)-type medical sources, utilizing ionization chambers, GM counters, and Monte Carlo methods. Unlike the previous methodologies, the present invention discloses a specification of dose to muscle, rather than dose to water, for clinical dosimetry of252Cf medical sources. A dosimetry protocol, similar to that utilized for ICRU-45, with parameters determined specifically for252Cf brachytherapy is disclosed. Neutron isodose distributions and data necessary for clinical implementation of252Cf AT sources are also disclosed herein. Additionally, novel methods for the encapsulation, storage, and delivery/implantation of252Cf radionuclide sources are disclosed.
REFERENCES:
patent: 4362940 (1982-12-01), Almond
patent: 4510924 (1985-04-01), Gray
patent: 4784116 (1988-11-01), Russell et al.
patent: H669 (1989-09-01), Fairchild et al.
patent: 5341292 (1994-08-01), Zamenhof
patent: 5776114 (1998-07-01), Frantzen et al.
patent: 5833593 (1998-11-01), Liprie
patent: 6267717 (2001-07-01), Stoll et al.
patent: 6352500 (2002-03-01), Halpern
patent: 2314798 (1973-04-01), None
patent: WO 94/25106 (1994-11-01), None
R. Nath et al.,Dosimetry of interstitial brachytherapy sources: Recommendations of the AAPM Radiation Therapy Committee Task Group No. 43. Med. Phys., vol. 22, No. 2, pp. 209-234 (1995).
M. J. Rivard,Neutron dosimetry, moderated energy spectrum, and neutron capture therapy for252Cf medical sources. Med. Phys., vol. 26, No. 3, pp. 495 (1999).
M. J. Rivard,Dosimetry for252Cf neutron emitting brachytherapy sources: Protocol, measurements, and calculations. Med. Phys., vol. 26, No. 8, pp. 1503-1514 (1999).
V. N. Ivanov, et al.,Dosimetry of Cf-252 Radiation: Studies in the USSR. Nuclear Science Applications, vol. 2, pp. 291-299, (1986).
M. J. Rivard et al.,Clinical brachytherapy with neutron emitting252Cf sources and adherence to AAPM TG-43 dosimetry protocol. Med. Phys., vol. 26, No. 1, pp. 87-96 (1999).
Y. A. Karelin et al.,Californium-252 Neutron Sources. Appl. Radiat. Isot. vol. 48, No. 10-12, pp. 1563-1566 (1997).
R. C. Martin et al.,Development of High-activity252Cf Sources for Neutron Brachytherapy. Appl. Radiat. Isot. vol. 48, No. 10-12, pp. 1567-1570 (1997).
ICRU Report No. 45,Clinical Neutron Dosimetry, Part 1: Determination of Absorbed Dose in a Patient Treated by External Beams of Fast Neutrons, International Commission on Radiation Units and Measurements, Issue Nov. 15, 1989.
AAPM Report No. 43,Quality Assessment and Improvement of Dose Response Models: Some Effects of Study Weaknesses on Study Findings. “C'Est Magnifique?”, Published for the American Association of Physics Publishing, Jun. 15, 1993.
A. Wambersie et al.,Present Status, Trends and Needs in Fast Neutron Therap, Buletin Du Cancer/Radiotherapie, 83/Suppl. vol. 1, pp. 68S-77S, 1996.
Gilbert Samuel G.
Hunter, Esq. Shane H.
Mintz Levin Cohn Ferris Glovsky and Popeo P.C.
New England Medical Center Hospitals Inc.
LandOfFree
Dosimetry for californium-252 ( 252 Cf) neutron-emitting... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Dosimetry for californium-252 ( 252 Cf) neutron-emitting..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dosimetry for californium-252 ( 252 Cf) neutron-emitting... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3638788