Dosage unit containing a substance showing a topical effect on t

Details Dosage unit containing a substance showing a topical effect on t Dosage unit containing a substance showing a topical effect on t

1974-11-18

1976-07-06

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

424 19, 424 22, 424 78, 424 83, 128260, 128261, 128271, 61K 952, 61K 31745, A61K 902, A61K 906

Patent

active

039682013

ABSTRACT:
A composition in the form of a solid shaped body adapted for insertion in the cavity of the eye and containing a substance having a topical effect on the eye, which composition comprises a mixture of 5 - 90 % of at least one lipophilic substance having a melting point of 37.degree. - 75.degree.C, 0 - 40 % of at least one water-soluble or water-swellable polymer in solid, finely-divided form, 0.05 - 30 % of at least one drug having a topical effect on the eye and 0.2 - 20 % of at least one water-insoluble lipophilic polymer having a softening temperature exceeding 70.degree.C and a melting point exceeding 85.degree.C and which is soluble in the lipophilic substance or substances in molten form to serve as stabilizer for the mixture, the percentages relating to percent by weight calculated on the total weight of the mixture.

REFERENCES:
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patent: 3574827 (1971-04-01), Beerbower
patent: 3670065 (1972-06-01), Eriksson et al.
patent: 3868445 (1975-02-01), Ryde et al.
Horsch et al. Chem. Abst. 52 No. 15830h (1958) "Washable Ointment Bases Formulated With Polyethylene".
Elsner et al. Chem. Abst. 75 No. 25343a (1971) "Use of Polyethylene Gel in Ophthalmic Ointment Containing Pilocarpine Hydrochloride".
Tice Chem. Abst. 22 No. 4723.sup.(7) (1928) "Notes on Three Ointments".
Wild Chem. Abst. 8 No. 989.sup.(3) (1914) "The official Ointments. . . Soft Paraffin as an Ointment Basis".
Thau et al. J. Soc. Cosmetic Chemists 16: 359-363 (1965) "A New Procedure for the Preparation of Polyethylene-Mineral Oil Gels".
Mutimer et al. J. A. Ph. A. Sci. Ed. XLV: 101-105, 212-218 (1956) "Modern Ointment Base Technology III".
Martin et al. J. A. Ph. A. Prac. Phy. Ed. XIV: 230-231 (1953) "Petrocera-A Versatile Ointment Base".
Lesser Drug & Cosm. Ind. 63 (3): 318-320, 402-407 (1948) "Ophthalmic Ointments".

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