Dosage forms of risedronate

Details Dosage forms of risedronate Dosage forms of risedronate

1994-09-14

1997-04-22

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424489, 424463, 424486, 424482, A61K 916, A61K 950

Patent

active

056227213

ABSTRACT:
The present invention is directed to a novel enteric-coated oral dosage form of a risedronate active ingredient comprised of a safe and effective amount of a pharmaceutical composition which is comprised of a risedronate active ingredient and pharmaceutically-acceptable excipients. Said dosage forms prohibit the exposure of the risedronate active ingredient to the epithelial and mucosal tissues of the buccal cavity, pharynx, esophagus, and stomach and thereby protects said tissues from erosion, ulceration or other like irritation. Accordingly, the said dosage forms effect the delivery to the lower gastrointestinal tract of said human or other mammal of a safe and effective amount of the risedronate active ingredient, and substantially alleviate the esophagitis or esophageal irritation which occasionally accompanies the oral administration of risedronate active ingredients.

REFERENCES:
patent: 4716041 (1987-12-01), Kjornaes
patent: 4786505 (1988-11-01), Lovgren
patent: 5096717 (1992-03-01), Wirth et al.
patent: 5431920 (1995-07-01), Bechard et al.

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