Surgery – Controlled release therapeutic device or system – Osmotic or diffusion pumped device or system
Patent
1986-08-11
1988-05-10
Rosenbaum, C. Fred
Surgery
Controlled release therapeutic device or system
Osmotic or diffusion pumped device or system
6048901, 424472, A61K 922
Patent
active
047432489
ABSTRACT:
A dosage form is disclosed, which dosage form comprises an outside wall and an inside wall, which inside wall comprises means for changing its structural integrity in response to fluid having a pH greater than 5 that enters the dosage form, thereby changing the pH environment inside the dosage form and concomitantly causing the inside wall to change its structural integrity, thus causing the outside wall to collapse and be easily eliminated from a host.
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Lappas et al., Polymeric Pharmaceutical Coating Materials I-Preparation and Properties, Feb. 1965, Journal of Pharmaceutical Sciences, vol. 54, No. 2, pp. 176-181.
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Barclay Brian
Bartoo Marc L.
Theeuwes Felix
Wong Patrick S.-L.
ALZA Corporation
Mandell Edward L.
Precivale Shelley G.
Rose Sharon E.
Rosenbaum C. Fred
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