Dosage form

Details Dosage form Dosage form

1991-10-04

1993-01-12

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424 7818, 424462, 424473, 424482, 424497, A61K 958, A61K 916

Patent

active

051788683

ABSTRACT:
The invention relates to an oral pharmaceutical multiple units formulation made up of individual cores containing a pharmacologically active substance, the cores being provided with a coating consisting essentially of a polymer that is insoluble in, impermeable to and non-soluble in water and in gastrointestinal fluids, and a water-soluble pore-creating substance, which is randomly distributed in said polymer, whereby said coated cores form units providing an essential zero order diffusion controlled release rate of said active substance. The invention also comprises a method of preparing these formulations.

REFERENCES:
patent: 3538214 (1970-11-01), Polii et al.
patent: 4256108 (1981-03-01), Theeuwes
patent: 4557925 (1985-12-01), Lindahl et al.
patent: 4606909 (1986-08-01), Bechgaard et al.
patent: 4687660 (1987-08-01), Baker et al.
patent: 4728513 (1988-03-01), Ventouras
patent: 4824678 (1989-04-01), Lindahl

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