Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-08-29
1997-09-23
Jagannathan, Vasu
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 13, 514 14, 514 21, 530399, 530326, 530327, 435 691, C07K 1446, C12N 1509, A61K 3816
Patent
active
056704810
ABSTRACT:
A novel and soluble polypeptide that is highly conserved among vertebrates has been discovered, which is designated "noggin." The properties of noggin include dorsal growth inducing activity. Noggin and activin act synergistically to produce dorsal mesoderm. Noggin's cDNA has been cloned. Several expression systems have been successfully used to express biologically active noggin. Amino acid sequences representing completely conserved portions as between frog noggin and mouse noggin are:
REFERENCES:
patent: 4857637 (1989-08-01), Hammonds et al.
patent: 4933294 (1990-06-01), Waterfield et al.
patent: 5030576 (1991-07-01), Dull et al.
patent: 5087616 (1992-02-01), Myers et al.
patent: 5098833 (1992-03-01), Lasky et al.
patent: 5126134 (1992-06-01), Heim et al.
patent: 5149637 (1992-09-01), Scandella et al.
Bowie et al. 1990. Science 247:1306-1310.
Barinaga. 1993. Science 262: 653-654.
Chen et al., "The Proto-Oncogene C-ros Codes for a Transmembrane Tyrosine Protein Kinase Sharing Sequence and Structural Homology . . .," Oncogene, 6 (1991), pp. 257-264.
Christian et al., "Xwnt-8, a Xenopus Wnt-1/int-1-related Gene Responsive to Mesoderm-inducing Growth Factors, May Play A Role in Ventral Mesodermal Patterning During Embryogenesis", Development, 111 (1991), pp. 1045-1055.
Sokol et al., "A Mouse Macrophage Factor Induces Head Structures and Organizes a Body Axis in Xenopus," Science, 249 (1990), pp. 561-564.
Weiss. 1993. Science 260 : 1072-1073.
Sambrook et al. 1989. Molecular Cloning: A Laboratory Manual. 2nd Ed., pp. 18.79-18.80.
Christian et al. Apr. 1991. Development 111:1045-1055.
Sokol et al. 1990. Science 249: 561-564.
Chen et al. Feb. 1991. Oncogene 6:257-264.
Chalazonitis et al., "Transforming Growth Factor .beta. Has Neurotrophic Actions on Sensory Neurons in Vitro and Is Synergistic with Nerve Growth Factor," Developmental Biology, 152, pp. 121-132 (1992).
Smith and Harland, "Expression Cloning of noggin, a New Dorsalizing Factor Localized to the Spemann Organizer in Xenopus Embryos," Cell, 70, pp. 829-840 (Sep. 4, 1992).
Smith et al., "Secreted noggin protein mimics the Spemann organizer in Dorsalizing Xenopus mesoderm," Nature, 361, pp. 547-549 (11 Feb. 1993).
Christian et al., "Xwnt-8 Modifies the Character of Mesoderm Induced by bFGF in Isolated Xenopus Ectoderm," The EMBO Journal, 11:1, pp. 33-41 (1992).
Condie and Harland, "Posterior Expression of a Homebox Gene in Early Xenopus Embryos," Development, 101, pp. 93-105 (1987).
Cooke, "Mesoderm-Inducing Factors and Spemann's Organiser Phenomenon in Amphibian Development," Development, 107, pp. 229-241 (1989).
Gallagher et al., "Autonomous Differentiation of Dorsal Axial Structures from an Animal Cap Cleavage Stage Blastomere in Xenopus," Development, 112, pp. 1103-1114 (1991).
Kimelman and Maas, "Induction of Dorsal and Ventral Mesoderm by Ectopically Expressed Xenopus Basic Fibroblast Growth Factor," Development, 114, pp. 261-269 (1992).
Kao and Elinson, "Dorsalization of Mesoderm Induction by Lithium," Developmental Biology, 132, pp. 81-90 (1989).
Slack et al., "Inductive Effects of Fibroblast Growth Factor and Lithium Ion on Xenopus Blastula Ectoderm," Development, 103, pp. 581-590 (1988).
Smith and Harland, "Injected Xwnt-8 RNA Acts Early in Xenopus Embryos to Promote Formation of a Vegetal Dorsalizing Center," Cell, 67, pp. 753-65 (Nov. 15, 1991).
Sokol et al., "Injected Wnt RNA Induces a Complete Body Axis In Xenopus Embryos," Cell, 67, pp. 741-752 (Nov. 15, 1991).
Harland Richard M.
Smith William C.
Jagannathan Vasu
Kemmerer Elizabeth C.
The Regents of the University of California
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