Dorrigocin antitumor agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546243, 546296, 514348, C07D21140, C07D21176, A61K 3144, A61K 31445

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active

055894852

ABSTRACT:
Novel antifungal and antitumor agents having the formula ##STR1## as well as pharmaceutically acceptable salts, esters, amides and pro-drugs thereof, wherein R is selected from the group consisting of ##STR2## Also disclosed are pharmaceutical compositions comprising such compounds, and methods of treatment and processes of manufacture relating thereto.

REFERENCES:
patent: 5002959 (1991-03-01), Konishi et al.
Chemical Abstracts, vol. 81(1) Abstract No. 2395d, Jul. 8, 1974.
Urakawa, et al., Isolation, Structure Determination and Biological Activities of a Novel Antifungal Antibiotic, S-632-C, Closely Related to Glutarimide Antibiotics, Journal of Antibiotics, vol. 46, No. 12, pp. 1827-1833 (Dec. 1993).
Otani, et al., New Glutarimide Antibiotics, S-632-B.sub.a and II. Isolution, Physico-Chemical Properties and Chemical Structure, The Journal of Antibiotics, May, 1989, vol. XLII, No. 5, pp. 654-661.
Otani, et al., New Glutarimide Antibiotics, S-632-B.sub.1 and B.sub.2 I. Taxonomy of Producing Strain, Fermentation and Biological Proprties, The Journal of Antibiotics, May, 1989, vol. XLII, No. 5, pp. 647-653.

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