Dopaminergic neuronal survival-promoting factors and uses...

Details Dopaminergic neuronal survival-promoting factors and uses... Dopaminergic neuronal survival-promoting factors and uses...

2009-08-04

2011-12-27

Kemmerer, Elizabeth C (Department: 1649)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S017700, C530S350000, C530S300000, C424S570000, C435S368000

Reexamination Certificate

active

08084425

ABSTRACT:
In general, the invention features substantially purified MANF and substantially purified nucleic acids encoding the same. The invention also features a pharmaceutical composition that includes MANF and a pharmaceutically-acceptable excipient, methods for treatment of a neurodegenerative disease, methods for improving dopaminergic neuronal survival during or following cell transplantation, methods for production of neurons for transplantation, and methods for identifying compounds that modulate or mimic MANF's biological activity.

REFERENCES:
patent: 2004/0006780 (2004-01-01), Gerber et al.
Petrova PS et al. MANF, A new mesencephalic, Astrocyte—derived neurotrophic factor with selectivity for dopaminergic neurons. J Mol Neurosci. 2003; 20(2):173-188.
Shridhar V et al. A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas. Oncogen, 1996; 12(9):1931-9. Abstract Only.

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