Dopaminergic agonist N,N-di-n-propyl-4-hydroxy-3-methanesulfonam

Details Dopaminergic agonist N,N-di-n-propyl-4-hydroxy-3-methanesulfonam Dopaminergic agonist N,N-di-n-propyl-4-hydroxy-3-methanesulfonam

1983-12-07

1985-03-26

Waltz, Thomas A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

260456A, 560109, 560251, 564 99, C07C14375, A61K 3118

Patent

active

045073201

ABSTRACT:
N,N-Di-n-propyl-4-hydroxy-3-methanesulfonamidophenethylamine is a potent, selective presynaptic dopaminergic agonist. The compound is prepared by N-sulfonylation of an optionally O-protected derivative of 3-amino-4-hydroxy-N,N-di-n-propylphenethylamine, followed by removal of the protecting group.

REFERENCES:
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patent: 4404224 (1983-09-01), Asato
Uloth et al., J. Med. Chem., vol. 99, pp. 88-96, (1966).
Larsen et al., CA 71: 30232k, (1969).
H. Sheppard et al., "Cyclic Nucleotides in Disease", University Park Press, 1974.

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