Dopamine transporter knockout mice

Details Dopamine transporter knockout mice Dopamine transporter knockout mice

1996-10-02

1999-02-02

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 800DIG3, 4351723, 424 91, 424 92, C12N 500, C12N 1500

Patent

active

058667563

ABSTRACT:
A recombinant rodent comprises cells containing a pair of genomic dopamine transporter protein alleles, wherein at least one of said alleles is incapable of expressing endogenous dopamine transporter protein. The rodent may be a homozygote, where both of said alleles are incapable of expressing endogenous dopamine transporter protein, or the rodent may be a heterozygote, and one of said alleles expresses endogenous dopamine transporter protein. The rodent is preferably a mouse.

REFERENCES:
patent: 5447948 (1995-09-01), Seibyl et al.
Simantov et al. Dopamine-induced apoptosis in human neuronal cells-inhibition by nucleic acids antisense to the dopamine transporter. Neuroscience, vol. 74, No. 1, pp. 39-50, Sep. 1996.
Orkin et al. Report and recommendations of the panel to assess the NIH investment in research on gene therapy, Dec. 7, 1995.
Gura, T. Antisense has growing pains. Science, vol. 270, pp. 575-577, Oct. 27, 1995.
Mullins et al. Transgenesis in nonmurine species. Hypertension, vol. 22, No. 4, pp. 630-633, Oct. 1993.
Fassler et al. Knockout Mice: How to make them and why. The immunological approach. Int Arch Allergy Immunol, vol. 106, pp. 323-334, 1995.
Miner et al.; Behavioral Characterization of Mutant Dopamine Transporter and Mu Opiate Receptor Overexpression in Catecholaminergic Neurons of Transgenic Mice, Society for Neuroscience Abstracts 20(1-2):921 (1994), (abstract).
F. Hucho; The Neurochemistry of Parkinson's Disease--Comments on Present (1995).

Affiliated with

Also associated with

Rating

Dopamine transporter knockout mice does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dopamine transporter knockout mice, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dopamine transporter knockout mice will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1118940