Dopamine receptor ligands and imaging agents

Details Dopamine receptor ligands and imaging agents Dopamine receptor ligands and imaging agents

1989-04-03

1991-11-26

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540 3, C07D28110

Patent

active

050683268

ABSTRACT:
Novel CNS dopamine D-1 receptors, such as the compound (.+-.)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-(4'-[.sup.125 I]iodophenyl)-1H-3-benzazepine-7-ol, are disclosed. These compounds are useful as imaging agents for D-1 receptors in the human brain and exhibit good brain retention and in vivo stability.

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