Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-10-06
1994-08-02
Berch, Mark L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548406, C07F 722, C07F 710, C07F 314, C07D40312
Patent
active
053347285
ABSTRACT:
Novel CNS dopamine D-2 receptors, such as the compound 5-iodo-7-N-[(1-ethyl-2-pyrrolidinyl)methyl]carboxamide-2,3-dihydrobenzofur an, are disclosed. These compounds are useful as imaging agents for D-2 receptors in the human brain and exhibit good brain retention and in vivo stability.
REFERENCES:
patent: 4656280 (1987-04-01), Garlick
patent: 4739060 (1988-04-01), Saji et al.
patent: 4888353 (1989-12-01), Lednicer et al.
patent: 5006570 (1991-04-01), Franceschini
Translation of Claim 1 of JP Kokai 58-62554 (1984).
Kung et al., Journal of Medicinal Chemistry, 331, 171-178, 1990.
Ogren, S. O. et al., European Journal of Pharmacology 102, 459-474, 1984.
Florvall, L. et al., J. Med. Chem. 25, 1280-1286, 1982.
De Paulis, T. et al., J. Med. Chem. 28, 1263-1269, 1985.
Hogberg, T. et al., Acta Pharm. Suec. 2424, 289-328, 1987.
Kohler, C. et al., Biochemical Pharmacology vol. 34 No. 13, 2251-2259, 1985.
Janowsky, A. et al., European Journal of Pharmacology 150, 203-205, 1988.
Kung, H. F. et al., Journal of Medicinal Chemistry 31, 1039, 1988.
Kung, H. F. et al., Nucl. Med. Biol. vol. 15 No. 2, 195-201, 1988.
Halldin, C. et al., Journal of Labelled Compounds and Radiopharmaceuticals vol. XXIII, Nos. 10-12, 1405-1406 (1986).
Farde, L. et al., Arch Gen. Psychiat. 44, 671, 1987.
Farde, L. et al., Psychopharmacology 94, 471-478, 1988.
European Patent Application Publication No. 147,044, published on Jul. 3, 1985.
U.K. Patent Application GB 2176785A, published on Jan. 7, 1987.
European Patent Application 207,913, published Jan. 7, 1987.
European Patent Application 234,872, published Sep. 2, 1987.
Kung, H. F. et al., Journal of Nuclear Medicine 30, 88, 1989.
Adam, M. J. et al., Int. J. Appl. Radiat. Isot. vol. 36 No. 12 935-937, 1985.
De Paulis Chemical Abstracts vol. 109, No. 15, Oct. 10, 1988 p. 665, column 2, Ref. No. 128757P.
Murphy et al. Chemical Abstracts, vol. 112, No. 5, Jan. 29, 1990, p. 555, column 2, Ref. No. 35611H.
Kung Hank F.
Murphy Raymond
Berch Mark L.
The Trustees of the University of Pennsylvania
LandOfFree
Dopamine receptor ligands and imaging agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Dopamine receptor ligands and imaging agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dopamine receptor ligands and imaging agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-65830