Dopamine hydroxylase inhibiting 2-amino-cyclopent-1-ene-1-thioca

Details Dopamine hydroxylase inhibiting 2-amino-cyclopent-1-ene-1-thioca Dopamine hydroxylase inhibiting 2-amino-cyclopent-1-ene-1-thioca

1977-12-29

1979-12-18

Evans, Joseph E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424325, C07C 8702, A61K 3113

Patent

active

041794672

ABSTRACT:
New 2-amino-cyclopent-1-ene-thiocarboxylic acid-disulfides of the formula, ##STR1## wherein R is a C.sub.1-6 alkyl group having optionally a C.sub.1-4 alkoxy, hydroxy, carboxy and/or amino substituent, a C.sub.2-4 alkenyl group, or a C.sub.3-8 cycloalkyl group, are prepared by oxidizing the respective 2-amino-cyclopent-1-ene-dithiocarboxylic acids of the formula, ##STR2## wherein R is as defined above. The compounds of the formula (I) exert dopamine-.beta.-hydroxylase inhibiting effects and can be applied in therapy.

REFERENCES:
Bordas et al., "J. Org. Chem.," vol. 37, (1972), pp. 1727-1730.
Takeshima et al., "J. Org. Chem.," vol. 34, (1969), pp. 730-732.

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