Dopamine D4 receptor antagonists

Details Dopamine D4 receptor antagonists Dopamine D4 receptor antagonists

1998-01-29

2000-07-11

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

51425301, 51425408, 514323, 544364, 544367, 544373, 546200, A61K 31496, C07D41714

Patent

active

060873647

ABSTRACT:
Compounds that are antagonists of dopamine D4 receptors, methods of treating psychosis and schizophrenia using the compounds, and pharmaceutically acceptable compositions that contain the dopamine D4 receptor antagonists are disclosed.

REFERENCES:
patent: 4355031 (1982-10-01), Demerson et al.
patent: 4999355 (1991-03-01), Comte et al.
patent: 5681954 (1997-10-01), Yamamoto et al.
Belliotti et al., "Isoindolinone Enantiomers Having Affinity for the Dopamine D4 Receptor," Bioorg. & Med. Chem. Let., vol. 8, No. 12, pp. 1499-1502, 1998.

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