Dopamine .beta.-hydroxylase inhibitors

Details Dopamine .beta.-hydroxylase inhibitors Dopamine .beta.-hydroxylase inhibitors

1982-04-05

1984-12-11

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424263, 435170, 546296, A61K 3500, A61K 3144, C12P 104, C07D40300

Patent

active

044877617

ABSTRACT:
Two fermentation isolates, C.sub.7 H.sub.9 NO.sub.4 and C.sub.6 H.sub.7 NO.sub.3, presumably trihydroxy, methyl-pyridine derivatives, are inhibitors of dopamine .beta.-hydroxylase. These natural product compounds are produced by fermentation of Streptoverticillium hiroshimense and each may prove useful as antihypertensive agents.

REFERENCES:
patent: 3914239 (1975-10-01), Kuhnis et al.
patent: 3998955 (1976-12-01), Kuhnis et al.
patent: 4009077 (1977-02-01), Tanabe et al.

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