Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-10-31
1986-12-09
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548263, 548265, A61K 3141, C07D24908
Patent
active
046280596
ABSTRACT:
Potent dopamine-.beta.-hydroxylase inhibitors having the Formula ##STR1## that are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity in mammals. Also disclosed are novel intermediates useful in preparing the presently invented inhibitors.
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Lin, Y., et al., J. Heterocyclic Chem., 17, 1077 (1980).
Finkelstein Joseph A.
Kaiser Carl
Kruse Lawrence I.
Bond Robert T.
Fabiano Vincent L.
Lourie Alan D.
SmithKlein Beckman Corporation
Suter Stuart R.
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