Dopamine-.beta.-hydroxylase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

548263, 548265, A61K 3141, C07D24908

Patent

active

046280596

ABSTRACT:
Potent dopamine-.beta.-hydroxylase inhibitors having the Formula ##STR1## that are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity in mammals. Also disclosed are novel intermediates useful in preparing the presently invented inhibitors.

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Modi, K. F., et al., J. Indian Chem. Soc., vol. LIV, pp. 741-742 (Jul. 1977).
Lin, Y., et al., J. Heterocyclic Chem., 17, 1077 (1980).

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