Dopamine and serotonin transporter ligands and imaging agents

Details Dopamine and serotonin transporter ligands and imaging agents Dopamine and serotonin transporter ligands and imaging agents

1998-07-16

1999-11-09

Dees, Jose' G.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 111, 424 137, 424 91, 424 145, 534 14, 546124, 546132, 514304, A61K 5100, A61M 3614

Patent

active

059808608

ABSTRACT:
This invention presents a series of novel tropane-based derivatives complexed with either technetium or rhenium that are specific for central nervous system receptors, in particular, dopamine or serotonin receptors. The compounds of the invention have utility, inter alia, as imaging agents for CNS receptors. Methods of using these novel compounds as imaging agents are presented, as are intermediates and methods for making these novel compounds

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O'Neil, J. e

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