Don-1 gene and polypeptides and uses therefor

Details Don-1 gene and polypeptides and uses therefor Don-1 gene and polypeptides and uses therefor

1999-09-17

2000-10-17

Allen, Marianne P.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530399, C07K 14475

Patent

active

061334235

ABSTRACT:
The present invention relates to the identification and characterization of a novel gene called don-1 related to epidermal growth factors (EGF) such as the neuregulins, and methods of preparing and using alternate splice forms of this gene to express new Don-1 polypeptides.

REFERENCES:
patent: 5912326 (1999-06-01), Chang
Ben-Baruch et al., "Neu Differentiation Factors: A Family of Alternatively Spliced Neuronal and Mesenchymal Factors" Proc. Soc. Exp. Biol. Med. 206:221-227, 1994.
Prigent et al., "The Type 1 (EGFR-Related) Family of Growth Factor Receptors and their Ligands" Prog. Growth Factor Res. 4:1-24, 1992.
Slamon et al., "Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2
eu Oncogene" Science 235:177-182, 1982.
Tzahar et al., "Erb-3 and ErbB-4 Function as the Respective Low and High Affinity Receptors of All Neu Differentiation Factor/Heregulin Isoforms" J. of Biol. Chem. 269:25226-25233, 1994.
Wen et al., "New Differentiation Factor: A Transmembrane Glycoprotein Containing an EGF Domain and an Immunoglobulin Homology Unit" Cell 69:559-572, 1992.

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