Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Reexamination Certificate
2007-02-01
2010-12-07
Skelding, Zachary (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
C424S145100, C530S387300, C530S388230
Reexamination Certificate
active
07846439
ABSTRACT:
The present invention provides a domain antibody construct which binds to human TNF-α, with the construct comprising:(a) a domain antibody (dAb) which binds to human TNF-α;(b) a modified hinge region sequence;(c) a human or primate heavy chain constant region sequence having a truncated CH1 domain of not more than 20 residues,wherein the modified hinge region sequence contains either a deletion or a single amino acid substitution of at least one cysteine residue which normally facilitates disulfide bond formation between heavy and light antibody chains.
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Chirin
Doyle Anthony G.
Jennings Philip A.
Lee Jennifer A.
Tomlinson Ian M.
Woolven Benjamin P.
Cephalon Australia Pty Ltd
Skelding Zachary
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