Dolastatin 15 derivatives

Details Dolastatin 15 derivatives Dolastatin 15 derivatives

2006-08-01

2006-08-01

Low, Christopher S. F. (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S016700, C514S017400, C530S328000, C530S329000, C530S330000

Reexamination Certificate

active

07084110

ABSTRACT:
Compounds of the present invention include cell growth inhibitors which are peptides of Formula I,in-line-formulae description="In-line Formulae" end="lead"?A-B-D-E-F-(G)r-(K)s-L,  (I)in-line-formulae description="In-line Formulae" end="tail"?and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a β-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

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