Dolastatin 15 derivatives

Details Dolastatin 15 derivatives Dolastatin 15 derivatives

1998-07-08

1999-11-16

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 17, 530330, 530333, 530338, A61K 3804, A61K 3808, A61K 3807, C07K 704

Patent

active

059858370

ABSTRACT:
Compounds of the present invention include cell growth inhibitors which are peptides of Formula I

REFERENCES:
patent: 4816444 (1989-03-01), Pettit et al.
patent: 5502032 (1996-03-01), Haupt et al.
patent: 5504191 (1996-04-01), Pettit et al.
patent: 5530097 (1996-06-01), Pettit et al.
patent: 5554725 (1996-09-01), Pettit
Pettit et al., Isolation of Dolastatin 10-15 from the Murine Mollusc Dolabella auricularia Tetrahedron vol. 49, No. 41, pp. 9151-9170, 1993.
Roux et al., Synthesis and In Vitro Cytotoxicity of Diasterioisomerically Modified Dolastatin 15 Analogues , Bioorganic and Medicinal Chemistry Letters, vol. 4, No. 16, pp. 1947-1950, 1944.
Pettit, G.R., et al., "The Isolation and Structure of a Remarkable Marine Animal Antineoplastic Constituent: Dolastatin 10," J. Am. Chem. Soc. 109:6883-6885 (1987).
Bai, R., et al., "Structure-Activity Studies with Chiral Isomers and with Segments of the Antimitotic Marine Peptide Dolastatin 10," Biochemical Pharmacology 40(8):1859-1864 (1990).
Pettit, G.R., et al. "Antineoplastic Agents. 220. Synthesis of Natural (-)-Dolastatin 15," J. Am. Chem. Soc. 113:6692-6693 (1991).
Bai, R., et al., "Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects on cellular microtubules," 1-Pharmacology Abstract 117: 103735g p. 41 (1992).
Pettit, G.R., et al., "Isolation and Structure of the Cytostatic Depsipeptide Dolastatin 13 from the Sea Hare Dolabella auricularia," J. Am. Chem. Soc. 111(13):5015-5017 (1989).
Pettit, G.R., et al., "Antineoplastic Agents 337. Synthesis of Dolastatin-10 Structural Modifications," Anti-Cancer Drug Design 10:529-544 (1995).
Miyazaki, K., et al., "Synthesis and Antitumor Activity of Novel Dolastatin-10 Analogs," Chem. Pharm. Bull. 43(10):1706-1718 (1995).
Pettit, G.R., et al., "Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15," J. Org. Chem. 54:6005-6006 (1989).
Pettit, G.R., et al., "The Dolastatins 20. A convenient synthetic route to Dolastatin 15." Tetrahedron 50(42):12097-12108 (1994).

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