Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1993-07-29
1995-05-30
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514570, A61K 3119
Patent
active
054201616
ABSTRACT:
The present invention relates to a method of weight and appetite suppression in an animal, including humans, in need of such treatment, by administering an effective amount of the (+), the (-) or the (.+-.) forms of one of the following compounds or derivatives thereof: ##STR1##
REFERENCES:
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Meyers, et al, "Doisynolic-Type Acids--Uterotropically Potent Estrogens Which Compete Poorly with Estradiol for Cytosolic Estradiol Receptors", J. steroid Biochem. vol. 31, No. 4A, 1988, pp. 393-404.
Soto, et al, "How Many Rings Can be Cleaved From a Steroidal Estrogen While Preserving Its Estrogenic Activity?" The Endocrine Society, 70th Annual Meeting, Abstract of Paper No. 1301, Jun. 1988.
Meyers and Kolb, "Facile and Selective Chlorination-Cleavage of Some Cyclanones and Cyclanols with the CC1.sub.4 -KOH-t-BUOH Reagent. In Situ Conversion of Estrones and Estradiols into Dichlorodoisynolic Acids.sup.1a ", J. Org. Chem., 1979, 44 (21), 3739, vol. 43, 1985 (1978), pp. 1985-1990.
Chemical Abstracts 67:40608u (1967).
Chemical Abstracts 75:128430f (1971).
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