Dog-mouse heterohybridoma and gene fragment coding for constant

Details Dog-mouse heterohybridoma and gene fragment coding for constant Dog-mouse heterohybridoma and gene fragment coding for constant

1996-05-08

1998-12-22

Ziska, Suzannne

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2353, 5303871, C07H 204, C07H 2102

Patent

active

058521836

ABSTRACT:
A gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of canine immunoglobulin lambda chain; a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of canine immunoglobulin kappa chain; a gene fragment which comprises a DNA sequence coding for the constant region of canine immunoglobulin gamma chain; a recombinant DNA molecule coding for an amino acid sequence of a mouse-dog chimeric antibody which comprises a gene fragment coding for an amino acid sequence of a variable region of a mouse immunoglobulin and a gene fragment coding for an amino acid sequence of a constant region of a canine immunoglobulin wherein the latter gene fragment; a polypeptide of a mouse-dog chimeric antibody which is expressed from a cell transformed with an expression vector for cells wherein said recombinant DNA molecule cording for an amino acid sequence of the mouse-dog chimeric antibody is incorporated; a dog-mouse heterohybridoma which produces canine immunoglobulin; and a process for preparing a canine immunoglobulin gene.

REFERENCES:
patent: 4842999 (1989-06-01), Fuller et al.
Bio Essays, vol. 8, No. 2, Feb./Mar. 1988, pp. 74-78; M. Verhoeven et al., Engineering of Antibodies".
Clinical Chemistry, vol. 34, No. 9, 1988, pp. 1668-1675; S.L. Morrison et al., "Production and Characterization of genetically engineered antibody . . . ".
Fuller et al., Fed. Proceedings 44(4); 1329, 1985 (Abst #5369.
Wasserman et al., Biochemistry 16(14); 3161, 1977.

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