Docosahexaenoic acid producing strains of Yarrowia lipolytica

Details Docosahexaenoic acid producing strains of Yarrowia lipolytica Docosahexaenoic acid producing strains of Yarrowia lipolytica

2005-11-01

2009-06-23

Nashed, Nashaat T (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Fungi

C435S254110, C435S134000, C435S189000, C536S023200

Reexamination Certificate

active

07550286

ABSTRACT:
An engineered strain of the oleaginous yeastYarrowia lipolyticacapable of producing greater than 5.6% docosahexaenoic acid acid (DHA, an w-3 polyunsaturated fatty acid) in the total oil fraction is described. This strain comprises various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprises various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of DHA. Production host cells are claimed, as are methods for producing DHA within said host cells.

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