DNT-maleate and methods of preparation thereof

Details DNT-maleate and methods of preparation thereof DNT-maleate and methods of preparation thereof

2006-09-21

2010-11-30

Solola, Taofiq A (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S075000

Reexamination Certificate

active

07842717

ABSTRACT:
(S)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine maleate (DNT-maleate) and polymorphs of DNT-maleate, compositions of DNT-maleate and its polymorphs, processes for the preparation of DNT-maleate and its polymorphs, and processes for the preparation of duloxetine hydrochloride from DNT-maleate are provided.

REFERENCES:
patent: 4314081 (1982-02-01), Molloy et al.
patent: 5023269 (1991-06-01), Robertson et al.
patent: 5362886 (1994-11-01), Berglund
patent: 5491243 (1996-02-01), Berglund
patent: 5508276 (1996-04-01), Anderson et al.
patent: 6541668 (2003-04-01), Kjell et al.
patent: 2005/0197503 (2005-09-01), Schiffers et al.
patent: 2006/0063943 (2006-03-01), Sakai et al.
patent: 2006/0194869 (2006-08-01), Ini et al.
patent: 2006/0270861 (2006-11-01), Ini et al.
patent: 2007/0167636 (2007-07-01), Butchko et al.
patent: 0 273 658 (1988-07-01), None
patent: 0 457 559 (1991-11-01), None
patent: 0 654 264 (1995-05-01), None
patent: 1 506 965 (2005-02-01), None
patent: WO 00/61540 (2000-10-01), None
patent: WO 03/070720 (2003-08-01), None
patent: WO 2004/031168 (2004-04-01), None
patent: WO 2004/056795 (2004-07-01), None
patent: WO 2005/108386 (2005-11-01), None
patent: WO 2006/027798 (2006-03-01), None
patent: WO 2006/045255 (2006-05-01), None
patent: WO 2006/096809 (2006-09-01), None
patent: WO 2006/099433 (2006-09-01), None
patent: WO 2006/126213 (2006-11-01), None
patent: WO 2007/077580 (2007-07-01), None
patent: WO 2007/096707 (2007-08-01), None
Deeter et al., Tetrahed. Letts. (1990), vol. 31(49), pp. 7101-7104.
Wheeler W. J., et al, “An Asymmetric Synthesis of Duloxetine Hydrochloride, a Mixed Uptake Inhibitor of Serotonin and Norepinephrine, and its C-14 Labeled Isotopomers”,J. Label .Cpds. Radiopharm, 36(3): 213-223 (1995).
Valenta, V. et al., “Potential Antidepressants: 3-aryl-3-(arylthio)propylamines as selective inhibitors of 5-hydroxytryptamine re-uptake in the brain”,Collection of Czechoslovak Chemical Communications, 56(7): 1525-1533 (1991).
Abdel-Monem, et al., “N-Demethylation of Morphine and Structurally Related Compounds With Chloroformate Esters”,J. Med. Chem., 1972, pp. 208-210, vol. 15, No. 2.
Deeter, et al., “Asymmetric Synthesis and Absolute Stereochemistry of LY248686”,Tetrahedron Letters, 1990, pp. 7101-7104, vol. 31, No. 49.
Kamal, et al., “Chemoenzymatic Synthesis of Duloxetine and Its Enantiomer: Lipase-Catalyzed Resolution of 3-Hydroxy-3-(2-Thienyl) Propanenitrile”,Tetrahedron Letters, 2003, pp. 4783-4787, vol. 44, No. 25.
Kometani, et al., “On the Cleavage of Tertiary Amines With Ethyl Chloroformate”,Chem. Pharm. Bull., 1976, pp. 342-349, vol. 24, No. 2.
Fujima, Yoshito et al., “Synthesis of (S)-3-(N-Methylamino)-1-(2-thienyl)propan-1-ol: Revisiting Eli Lilly's Resolution-Racemization-Recycle Synthesis of Duloxetine for Its Robust Processes,”Organic Process Research&Development, 10(5): 905-913 (2006).
Sakai, K. et al., “Resolution of 3-(methylamino)-1-(2-thienyl)propan-1-ol, a new key intermediate for duloxetine, with (S)-mandelic acid,”Tetrahedron: Asymmetry, 14(12): 1631-1636 (2003).
L.A. Sorbera, et al., “Duloxetine Oxalate”,Drugs of the Future, vol. 25, No. 9, pp. 907-916, (2000).

Affiliated with

Also associated with

Rating

DNT-maleate and methods of preparation thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNT-maleate and methods of preparation thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNT-maleate and methods of preparation thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4149742