Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-03-01
1997-07-29
Ulm, John
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 695, 4351723, 4352523, 4353201, 935 11, 935 22, 935 70, 935 73, C12N 1528, C07K 14525
Patent
active
056523530
ABSTRACT:
It is an object of this invention to provide a human Tumor Necrosis Factor mutein or a pharmaceutically acceptable salt thereof characterized in that the TNF sequence is changed by a deletion, insertion, substitution or combinations thereof, of one or more amino acids so that the mutein shows a significant difference between its binding affinity to the human p75-Tumor-Necrosis-Factor-Receptor and to the human p55-Tumor-Necrosis-Factor-Receptor. The invention also includes DNA sequences coding for such muteins, vectors comprising such DNA sequences, host cells transformed with such vectors and a process for the production of such muteins employing such transformed host cells and pharmaceutical compositions containing such muteins and their use for the treatment of illnesses, for example cancer.
REFERENCES:
patent: 4650674 (1987-03-01), Aggarwal et al.
patent: 4948875 (1990-08-01), Tanaku et al.
patent: 4990455 (1991-02-01), Yamagishi et al.
English Abstract for Document B7.
English Abstract for Document B6 (J63/91590).
Tsujimoto, et al. J. Biochem. 101, 919-925 (1987).
Masegi, et al. Protein Engineering 375-376 (1989).
Yamagishi, et al. Protein Engineering, vol. 3, No. 8, 713-719 (1990).
Tsukio, Patent Abstract of Japan, vol. 13, No. 119 (1989).
Ostade, et al. The Embo Journal, vol. 10, No. 4 827-836 (1991).
Tartaglia, et al, Immunology Today, vol. 13, No. 5, (1992).
Barrett, et al. Eur. Journal Immunology vol. 21, 1649-1656 (1991).
Lewis, et al. Proc. Natl. Acad. Science vol. 88, 2830-2834 (1991).
Yamagishi, et al. Protein Eng. 3(4) 372 (abst. only) (1990).
Wills, et al. Science 243, 1330-1336 (1989).
Goh, et al. Protein Eng. 4 (7) 785-791 (1991).
Zavernier, et al. J. Mol. Biol. 211(2) 493-502 (1990).
Eck et al, JBC, 264 17595-06, (1989).
Bowie et al. (1990) Science, vol. 247, pp. 1306-1310.
Fiers Walter
Tavernier Jan
Van Ostade Xaveer
Epstein William H.
Hoffman-La Roche Inc.
Johnston George W.
Kreisler Lewis J.
Mertz Prema
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