DNAs encoding guinea pig histamine receptors of the H4 subtype

Details DNAs encoding guinea pig histamine receptors of the H4 subtype DNAs encoding guinea pig histamine receptors of the H4 subtype

2006-10-03

2006-10-03

Li, Ruixiang (Department: 1646)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C435S325000, C435S252300, C435S254110, C435S254200, C536S023500, C530S350000

Reexamination Certificate

active

07115395

ABSTRACT:
DNAs encoding the mammalian histamine H4 receptors have been cloned and characterized. These recombinant molecules are capable of expressing biologically active histamine H4 receptor protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The pharmacology of known histamine ligands is demonstrated. The recombinant protein may be purified from the recombinant host cells. In addition, recombinant host cells are utilized to establish methods to identify modulators of the receptor activity, and receptor modulators are identified.

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