DNAs encoding genetically engineered low oxygen affinity mutants

Details DNAs encoding genetically engineered low oxygen affinity mutants DNAs encoding genetically engineered low oxygen affinity mutants

1989-10-06

1992-12-22

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 696, 4351723, 4353201, 536 27, C12N 1570, C12N 1574, C12N 1512

Patent

active

051734265

ABSTRACT:
A substantially pure polynucleotide coding for an alpha and/or beta human globin, the globin when part of a hemoglobin molecule confering lower oxygen affinity than normal hemoglobin to result in a mutant hemoglobin, the mutant hemoglobin having an oxygen affinity measured for stripped hemoglobin characterized by a P.sub.50 of 30 torr to 3 atmospheres and/or by a Hill coefficient between 2.5 and 1.0. Such mutant hemoglobin being useful to increase tissue oxygenation in a patient, to replace hemoglobin in the bloodstream of a patient and to treat patients suffering from burns.

REFERENCES:
patent: 5028588 (1991-07-01), Hoffman
Suggs et al. PNAS 78: 6613 (1981).
Fioretti et al. Biochem. Biophy. Res Comm 68:1169 (1976).
Barra et al. FEBS Lett. 64:76 (1976).
Dickerson, Hemoglobin: Structure, function, evolution, & pathology. Benjamin/Cummings pubs. Calif. 1983.

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