Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1992-02-21
1993-12-07
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
435 691, 4351723, 4353201, 435942, 536 235, C12N 121, C12N 1515, C12N 1509, C12N 1574
Patent
active
052682960
ABSTRACT:
Novel polypeptides, designated hirullins, have a strong antithrombic activity and can therefore be used for the therapy and prophylaxis of thromboses. Said compounds are isolated from the leech Hirudinaria manillensis or are produced by conventional peptide synthesis or by recombinant DNA techniques. DNA sequences encoding hirullins P6 and P18 are supplied, hybrid vectors and transformed microorganisms for recombinant hirullin production are supplied.
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Grutter Markus G.
Maschler Reinhard
Steiner Verena
Ciba-Geigy Corporation
Foley Shawn P.
UCP Gen-Pharma AG
Walsh Stephen
Wax Robert A.
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