Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2008-04-08
2008-04-08
Wehbe, Anne M. (Department: 1633)
Chemistry: molecular biology and microbiology
Vector, per se
C435S455000, C514S04400A
Reexamination Certificate
active
10466347
ABSTRACT:
The present invention relates to a method for inducing the immune response of an individual against B-lymphoproliferative disorders. The method is based on DNA vaccination with the short peptide encompassing the CDR3 hypervariable region of immunoglobulin heavy chain (VH-CDR3) alone or in combination with at least another immunomodulating sequence.
REFERENCES:
patent: WO-95/05853 (1995-03-01), None
Rinaldi et al. (1998) Gene Ther. Canc., vol. 451, 323-330.
Raaphorst et al. (1996) Biotechniques, vol. 20 (1), 78, 80-87.
Ramasamy et al. (1992) J. Clin. Pathol., vol. 45, 770-775.
Syrengelas A D et al.: “DNA Immunization Induces Protective Immunity Against B-Cell Lymphoma”; Nature Medicine, Nature America, New York, US.; vol. 2, No. 9, Sep. 1996; pp. 1038-1041, XP 000996399.
Stevenson F K et al.: “Idiotypic DNA Vaccines Against B-Cell Lymphoma”; Immunological Reviews, Munksgaard, XX, vol. 145, Jun. 1, 1995, pp. 211-228, XP 000670867.
Rinaldi M. et al.; “Startegies to Elicit Anti-Idiotypic Immune Response in B-Lymphoma Patients: Peptide and Genetic Immunization”; Adv. Exp. Med. Biol., vol. 451,—1998, pp. 323-330, XP 001005261.
Wen Y.J. et al.;“In-Vivo Immune Responses to Idiotypic VH Complementarity-Determining Region 3 Peptide Vaccination in B-Cell Non-Hodgkins Lymphoma”; Brit. J. of Haematology, vol. 103, No. 3, Dec. 1998; XP 001005275.
Campbell M J et al.; “Immunotherapy of Established Murine B Cell Lymphoma. Combination of Idiotype Immunization and Cyclophosphamide”; Journal of Immunology, US, The Williams and Wilkins Co. Baltimore; vol. 141, No. 9, Nov. 1, 1998, pp. 3227-3233; XP 002036673.
Xiong S et al; “Engineering Vaccines With Heterologous B and T Cell Epitopes Using Immunoglobulin Genes”; Nature Biotechnology, Nature Pub. Co., New York, NY, US; vol. 15, No. 9, Sep. 1997, pp. 882-886; XP 000918882.
Irvine K R et al; “Cytokine Enhancement of DNA Immunization Leads to Effective Treatment of Established Pulmonary Metastases”; Journal of Immunology, US, The Williams and Wilkins Co., Baltimore; vol. 156, 1996, pp. 238-245; XP 002030631.
Rinaldi, et al., Antibodies Elicited by Naked DNA Vaccination against the Complementary-determining Region 3 ypervariable Region of Immunoglobulin Heavy Chain Idiotypic Determinants of B-lymphoproliferative Disorders Specifically React with Patients' TumorCells1. Cancer Research 61, Feb. 12, 2001, pp. 1555-1562.
Fazio Vito M.
Saglio Giuseppe
Darby & Darby P.C.
Keryos SpA
Wehbe Anne M.
LandOfFree
DNA vaccines expressing hypervariable VH-CDR3 idiotypic... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with DNA vaccines expressing hypervariable VH-CDR3 idiotypic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA vaccines expressing hypervariable VH-CDR3 idiotypic... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3932839