DNA vaccines against tumor growth and methods of use thereof

Details DNA vaccines against tumor growth and methods of use thereof DNA vaccines against tumor growth and methods of use thereof

2009-08-04

2011-11-08

Li, Q. Janice (Department: 1633)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C424S093200, C424S093210, C435S320100

Reexamination Certificate

active

08053421

ABSTRACT:
A DNA vaccine suitable for eliciting an immune response against cancer cells comprises a polynucleotide construct operably encoding an a Fra-1 protein, such as a polyubiquitinated human Fra-1 protein, and IL-18, such as human IL-18, in a pharmaceutically acceptable carrier. In a preferred embodiment, the polynucleotide construct is operably incorporated in an attenuated bacterial vector, such as an attenuatedSalmonella typhimurium, particularly a doubly attenuated aroA−dam−S. typhimurium. Transformed host cells, methods of inhibiting tumor growth, of vaccinating a patient against cancer, and of delivering genetic material to a mammalian cell in vivo are also described.

REFERENCES:
patent: 7132407 (2006-11-01), Lai et al.
patent: 7569552 (2009-08-01), Luo et al.
Weth et al. Cancer Gene Ther 2001;8:599-611.
Zajchowski et al. Cancer Res 2001;61:5168-78.
Asad et al. Mole Ther 2002;5:609-16.
Luo et al. PNAS 2003;100:8850-5.
Rosenkranz et al. Vaccine Jan. 2003;21:798-801.
Darnell et al. Nat Rev Cancer 2002;2:740-9.

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