Chemistry: molecular biology and microbiology – Vector – per se
Patent
1995-04-20
1997-04-15
Stone, Jacqueline M.
Chemistry: molecular biology and microbiology
Vector, per se
514 44, C12N 1563, A61K 4800
Patent
active
056208960
ABSTRACT:
This invention relates to methods of eliciting an immune response and/or protective immunity in a vertebrate by introducing into the vertebrate a DNA vaccine which consists essentially of DNA encoding an antigen or antigens, e.g., capsid proteins or polypeptides, of rotavirus. The uptake of the DNA vaccine by a host vertebrate results in the expression of the capsid protein, thereby eliciting humoral or cell-mediated immune responses, or both, which can provide protection against infection and/or prevent clinically significant rotavirus-caused disease. In addition, the invention demonstrates that an internal vital antigen provides protective immunity in a host. The host can be any vertebrate, including birds, piglets, and humans.
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Fynan Ellen F.
Herrmann John E.
Robinson Harriet L.
Hogue, Jr. D. Curtis
Stone Jacqueline M.
University of Massachusetts Medical Center
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